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WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus

PMC / Molecular Biology

Abstract

This study highlights WDR23 as a specific molecular mechanism influencing NRF2 proteostasis in the hippocampus. WDR23 represents a KEAP1-independent pathway for NRF2 regulation with implications for Alzheimer's disease and cognitive function.

Key Findings

  • WDR23 identified as novel KEAP1-independent NRF2 regulator in hippocampus
  • WDR23 mediates NRF2 degradation through distinct pathway from KEAP1
  • Hippocampal NRF2 regulation has implications for memory and learning
  • New therapeutic target for brain-specific NRF2 enhancement

Clinical Significance

Discovery of KEAP1-independent NRF2 regulation in the brain's memory center. Opens new avenue for targeting NRF2 specifically in the hippocampus.

Citation

WDR23 mediates NRF2 in the hippocampus. (2024). PMC10939789.

DOI: 10.1016/j.molcel.2024.01.005