Oxidative Stress
Apigenin combined with aerobic exercise alleviates oxidative stress and inflammation in high-fat diet-induced NAFLD mice by modulating the Keap1/Nrf2/ARE pathway.
Scientific reports 2026-Mar-21
Huang Nixi, Peng Lina, Huang Enhui, Qin Ying, Li Hongjie, Liao Jiangrui, Wang Yu, Shi Lei, Sun Lili
Abstract
Key Findings
- Apigenin combined with aerobic exercise reduces oxidative stress in high-fat diet-induced NAFLD mice.
- The combination therapy alleviates inflammation in the liver of NAFLD mice.
- The protective effects are mediated through modulation of the Keap1/Nrf2/ARE antioxidant pathway.
Clinical Significance
This study suggests that combining apigenin with aerobic exercise may offer a therapeutic strategy to mitigate oxidative stress and inflammation in NAFLD patients by targeting the Keap1/Nrf2/ARE pathway.
Citation
Huang Nixi, Peng Lina, Huang Enhuiet al.. Apigenin combined with aerobic exercise alleviates oxidative stress and inflammation in high-fat diet-induced NAFLD mice by modulating the Keap1/Nrf2/ARE pathway. Scientific reports. 2026-Mar-21.
DOI: 10.1038/s41598-026-45268-9