Ferroptosis

Corrigendum to <'Melatonin reduces radiation-induced ferroptosis in hippocampal neurons by activating the PKM2/NRF2/GPX4 signaling pathway'> <[Progress in Neuro-psychopharmacology and Biological Psychiatry. 2023 Aug 30:126:110777]>.

Progress in neuro-psychopharmacology & biological psychiatry 2026-Jun-20

Ren Chen, Tan Peixin, Gao Lianxuan, Zeng Yingying, Hu Shushu, Chen Chen, Tang Nan, Chen Yulei, Zhang Wan, Qin Yue, Zhang Xiaonan, Du Shasha

Abstract

Key Findings

Melatonin reduces radiation-induced ferroptosis in hippocampal neurons.
The protective effect is mediated by activation of the PKM2/NRF2/GPX4 signaling pathway.
Activation of this pathway helps in mitigating neuronal damage caused by radiation.

Clinical Significance

This study suggests that melatonin could be a potential therapeutic agent to protect hippocampal neurons from radiation-induced damage by inhibiting ferroptosis, which may have implications for improving outcomes in patients undergoing radiation therapy.

Citation

Ren Chen, Tan Peixin, Gao Lianxuanet al.. Corrigendum to <'Melatonin reduces radiation-induced ferroptosis in hippocampal neurons by activating the PKM2/NRF2/GPX4 signaling pathway'> <[Progress in Neuro-psychopharmacology and Biological Psychiatry. 2023 Aug 30:126:110777]>. Progress in neuro-psychopharmacology & biological psychiatry. 2026-Jun-20.

DOI: 10.1016/j.pnpbp.2026.111668