Oxidative Stress
[Retracted] Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling.
Experimental and therapeutic medicine 2026-Jun
Yu Jianyong, Yang Yang, Li Shan, Meng Peng
Abstract
[This retracts the article DOI: 10.3892/etm.2021.10378.].
Key Findings
- Salinomycin induces apoptosis in prostate cancer cells.
- The mechanism involves inducing oxidative stress and endoplasmic reticulum stress.
- This effect is mediated through suppression of Nrf2 signaling.
Clinical Significance
Targeting Nrf2 signaling with agents like salinomycin may provide a therapeutic strategy for inducing apoptosis in prostate cancer cells by enhancing oxidative and ER stress.
Citation
Yu Jianyong, Yang Yang, Li Shanet al.. [Retracted] Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling. Experimental and therapeutic medicine. 2026-Jun.
DOI: 10.3892/etm.2026.13166