Oxidative Stress

[Retracted] Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling.

Experimental and therapeutic medicine

Abstract

[This retracts the article DOI: 10.3892/etm.2021.10378.].

Key Findings

  • Salinomycin induces apoptosis in prostate cancer cells.
  • The mechanism involves inducing oxidative stress and endoplasmic reticulum stress.
  • This effect is mediated through suppression of Nrf2 signaling.

Clinical Significance

Targeting Nrf2 signaling with agents like salinomycin may provide a therapeutic strategy for inducing apoptosis in prostate cancer cells by enhancing oxidative and ER stress.

Citation

Yu Jianyong, Yang Yang, Li Shanet al.. [Retracted] Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling. Experimental and therapeutic medicine. 2026-Jun.

DOI: 10.3892/etm.2026.13166