Correction to "Targeting the Interaction of NRF2 and β-TrCP with Molecular Glues".
O Donovan Daniel H, Winter-Holt Jon, Collie Gavin W, Cuomo Maria E, McGarry David John, Fox Millie, Seong Bo Kyung Alex, Grazini Ursula, Barton Peter, Longmire David, Lister Andrew, Xu Yong, Mak Hazel, Barrey Evelyne J, Acebrón-García-de-Eulate Marta, Richter Magdalena, Peter Nisha, Couturier Maxime, Gutierrez Gustavo J, Guilbert Ryan, Lee Wankyu, Lochhead Pamela A, Argyrou Argyrides
Abstract
Key Findings
- The study focuses on targeting the interaction between NRF2 and β-TrCP using molecular glues.
- Molecular glues can modulate protein-protein interactions to influence NRF2 stability and activity.
- Correcting the interaction between NRF2 and β-TrCP offers a novel approach for therapeutic intervention.
Clinical Significance
This research highlights a promising strategy for drug development by modulating NRF2 pathways, which could lead to new treatments for diseases where NRF2 plays a critical role, such as cancer and oxidative stress-related conditions.
Citation
O Donovan Daniel H, Winter-Holt Jon, Collie Gavin Wet al.. Correction to "Targeting the Interaction of NRF2 and β-TrCP with Molecular Glues". ACS chemical biology. 2026-Jun-19.