Neurodegenerative

Corrigendum to"Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway" [Behavioural Brain Res. 495 (2025) 115805].

Behavioural brain research 2026-Oct-02

Luo Weigang, Bu Wei, Zhang Guisong, Dong Yujuan, Wang Yuling, Wang Jinyang, Liu Cuicui, Hu Xiaokai, Jia Yanan, Ren Huiling

Abstract

Key Findings

Downregulation of Nrf2 worsens cognitive impairment in APP/PS1 mice.
Nrf2 downregulation inhibits mitochondrial biogenesis.
The effect is mediated through the PPARγ/PGC1α signaling pathway.

Clinical Significance

Targeting Nrf2 to enhance mitochondrial biogenesis via the PPARγ/PGC1α pathway may offer therapeutic potential for cognitive impairment in neurodegenerative diseases such as Alzheimer's.

Citation

Luo Weigang, Bu Wei, Zhang Guisonget al.. Corrigendum to"Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway" [Behavioural Brain Res. 495 (2025) 115805]. Behavioural brain research. 2026-Oct-02.

DOI: 10.1016/j.bbr.2026.116377