Oxidative Stress

Ozone-driven NRF2 activation boosts osteoblast activity: Implications for skeletal diseases.

Biochimica et biophysica acta. Molecular basis of disease 2026-Jul-26

Sala Alessandra, Dominoni Mattia, Spinillo Arsenio, Forlino Antonella, Besio Roberta

Abstract

Key Findings

Ozone exposure activates NRF2 signaling pathways.
NRF2 activation enhances osteoblast activity.
Enhanced osteoblast activity suggests potential benefits for skeletal diseases.

Clinical Significance

Activation of NRF2 through ozone treatment may offer a novel therapeutic approach to improve bone formation and treat skeletal disorders related to impaired osteoblast function.

Citation

Sala Alessandra, Dominoni Mattia, Spinillo Arsenioet al.. Ozone-driven NRF2 activation boosts osteoblast activity: Implications for skeletal diseases. Biochimica et biophysica acta. Molecular basis of disease. 2026-Jul-26.

DOI: 10.1016/j.bbadis.2026.168386