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Neurodegenerative

Expression of Concern: "Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease'' [BBR, 336 (2018) pp 219-226].

Behavioural brain research

Abstract

Key Findings

  • Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione shows neuroprotective effects in a mouse model of Alzheimer's disease
  • The study highlights the potential role of Nrf2 activation in mitigating neurodegeneration
  • Expression of concern indicates the need for cautious interpretation of the original findings

Clinical Significance

Activation of the Nrf2 pathway may offer a therapeutic strategy for neuroprotection in Alzheimer's disease, though further validation is necessary due to concerns raised about the study.

Citation

. Expression of Concern: "Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease'' [BBR, 336 (2018) pp 219-226]. Behavioural brain research. 2026-Oct-02.

DOI: 10.1016/j.bbr.2026.116388