NRF2.com
Back to Research
Oxidative Stress

Evading disulfidptosis via NRF2 translation.

Nature cell biology

Abstract

Key Findings

  • NRF2 translation plays a critical role in evading disulfidptosis, a form of cell death associated with oxidative stress.
  • Modulation of NRF2 activity can influence cellular resistance to oxidative damage.
  • Targeting NRF2-mediated pathways may provide a protective mechanism against oxidative stress-induced cell death.

Clinical Significance

Understanding NRF2's role in preventing disulfidptosis highlights its potential as a therapeutic target to mitigate oxidative stress-related diseases and improve cell survival in pathological conditions.

Citation

Baird Liam, Yamamoto Masayuki. Evading disulfidptosis via NRF2 translation. Nature cell biology. 2026-Aug-14.

DOI: 10.1038/s41556-026-02036-1