Oxidative Stress

Kirenol attenuates heart failure by activating the Nrf2/HO-1 pathway in macrophages.

International journal of cardiology 2026-Sep-18

Wang Hui-Hui, Song Dan-Dan, Wang Feng-Yi, Wang Xiao-Mei, Ren Kun

Abstract

Key Findings

Kirenol activates the Nrf2/HO-1 pathway in macrophages.
Activation of the Nrf2/HO-1 pathway by Kirenol attenuates heart failure.
Targeting macrophage Nrf2/HO-1 signaling may provide therapeutic benefits in heart failure.

Clinical Significance

Kirenol's activation of the Nrf2/HO-1 pathway in macrophages offers a potential therapeutic strategy to mitigate heart failure by reducing oxidative stress and inflammation.

Citation

Wang Hui-Hui, Song Dan-Dan, Wang Feng-Yiet al.. Kirenol attenuates heart failure by activating the Nrf2/HO-1 pathway in macrophages. International journal of cardiology. 2026-Sep-18.

DOI: 10.1016/j.ijcard.2026.134935