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Oxidative Stress

Statement of Retraction: Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway.

Bioengineered

Abstract

Key Findings

  • Recombinant human klotho protects human retinal pigment epithelial cells from hydrogen peroxide-induced injury.
  • Protection is mediated via the PI3K/Akt-Nrf2/HO-1 signaling pathway.
  • The study highlights the role of Nrf2 in cellular defense against oxidative stress.

Clinical Significance

Understanding the protective mechanisms of recombinant human klotho via Nrf2 signaling may inform therapeutic strategies to prevent or treat oxidative stress-related retinal diseases.

Citation

. Statement of Retraction: Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway. Bioengineered. 2026-Dec.

DOI: 10.1080/21655979.2026.2730757