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Oxidative Stress

Statement of Retraction: Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway.

Bioengineered

Abstract

Key Findings

  • Gastrodin protects retinal ganglion cells from ischemic injury
  • Protection is mediated by activation of the PI3K/AKT/Nrf2 signaling pathway
  • Nrf2 activation plays a key role in cellular defense against oxidative stress in retinal cells

Clinical Significance

These findings suggest that gastrodin could be a potential therapeutic agent for ischemic retinal diseases by enhancing antioxidant defenses through the Nrf2 pathway.

Citation

. Statement of Retraction: Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway. Bioengineered. 2026-Dec.

DOI: 10.1080/21655979.2026.2731814