Recent developments in the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases.

Abstract

INTRODUCTION: Inflammatory bowel disease (IBD) is a chronic and relapsing disorder of the gastrointestinal tract. Its prevalence has risen rapidly, and nowadays it is a global health concern. Currently available medications reduce inflammation and alleviate the symptoms, but do not cure the disease. Recent findings suggest that dysregulated redox homeostasis may contribute to IBD progression, positioning oxidative stress as one of the primary mechanisms driving inflammation. AREAS COVERED: Data for this review were identified through a comprehensive search of PubMed and Google Scholar for the period from February 2013 to September 2026. This review aims to describe recent approaches focused on oxidative stress and IBD, including the use of oxidative stress biomarkers, treatment options employing neutrophils and nanoparticles, the emerging role of the Nrf2 signaling pathway, ferroptosis suppression, and oxidative stress-related changes in the microbiome. Furthermore, inflammaging and dietary interventions are discussed in the context of oxidative stress, as they modulate redox homeostasis and influence inflammatory pathways. EXPERT OPINION: A better understanding of the interplay between ROS, inflammation, microbiome, and dietary interventions may provide valuable insights into mechanisms underlying IBD pathology, while targeting these pathways may facilitate the development of novel, adjunctive therapeutic approaches in IBD management.

Key Findings

• Dysregulated redox homeostasis contributes to the progression of inflammatory bowel disease (IBD).
• The Nrf2 signaling pathway plays an emerging role in modulating oxidative stress in IBD.
• Targeting oxidative stress through biomarkers, neutrophil and nanoparticle-based treatments, ferroptosis suppression, and dietary interventions may offer novel therapeutic strategies.

Clinical Significance

Citation

Merecz Karolina, Jarząbek Julia, Fichna Jakub. Recent developments in the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases. Expert review of gastroenterology & hepatology. 2026-Oct-03.