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Oxidative Stress

Statement of Retraction: Melatonin alleviates lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced pyroptosis in rat alveolar Type II cells (RLE-6TN) through nuclear factor erythroid 2-related factor 2 (Nrf2)-driven reactive oxygen species (ROS) downregulation.

Bioengineered

Abstract

Key Findings

  • Melatonin alleviates LPS/ATP-induced pyroptosis in rat alveolar Type II cells.
  • The protective effect is mediated through Nrf2-driven downregulation of reactive oxygen species (ROS).
  • Nrf2 plays a key role in modulating oxidative stress and inflammatory cell death in lung cells.

Clinical Significance

This study highlights the potential of melatonin to reduce lung cell injury caused by inflammatory stimuli via Nrf2 activation, suggesting a therapeutic avenue for conditions involving oxidative stress and pyroptosis in pulmonary diseases.

Citation

. Statement of Retraction: Melatonin alleviates lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced pyroptosis in rat alveolar Type II cells (RLE-6TN) through nuclear factor erythroid 2-related factor 2 (Nrf2)-driven reactive oxygen species (ROS) downregulation. Bioengineered. 2026-Dec.

DOI: 10.1080/21655979.2026.2745583