NRF2.com
Back to Research
Oxidative Stress

Statement of Retraction: Ramelteon protects against human pulmonary microvascular endothelial cell injury induced by lipopolysaccharide (LPS) via activating nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway.

Bioengineered

Abstract

Key Findings

  • Ramelteon protects human pulmonary microvascular endothelial cells from injury induced by lipopolysaccharide (LPS).
  • The protective effect is mediated via activation of the Nrf2/HO-1 pathway.
  • Activation of the Nrf2/HO-1 pathway plays a role in cellular defense against oxidative damage.

Clinical Significance

Targeting the Nrf2/HO-1 pathway with agents like Ramelteon may offer therapeutic potential in treating pulmonary endothelial injury caused by inflammatory stimuli such as LPS.

Citation

. Statement of Retraction: Ramelteon protects against human pulmonary microvascular endothelial cell injury induced by lipopolysaccharide (LPS) via activating nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Bioengineered. 2026-Dec.

DOI: 10.1080/21655979.2026.2745614